ABC-transporters and lipid transfer proteins : important players in macrophage cholesterol homeostasis and atherosclerosis

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ABC-transporters and lipid transfer proteins : important players in macrophage cholesterol homeostasis and atherosclerosis

Type: Doctoral Thesis
Title: ABC-transporters and lipid transfer proteins : important players in macrophage cholesterol homeostasis and atherosclerosis
Author: Ye, Dan
Publisher: Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research
Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2008-11-04
Keywords: ABC-transporters
atherosclerosis
Lipid transfer proteins
Abstract: Local modulation of macrophage cholesterol metabolism in the arterial wall and systemic regulation of lipoprotein metabolism (LDL-lowering and/or HDL-raising) are both attractive targets for future drug design for the prevention of atherosclerosis. As described in this thesis, bone marrow transplantation can be considered a useful strategy to study the role of macrophage-expressing genes and gene products in lipoprotein metabolism and atherogenesis, which may lead to the identification of target genes for pharmaceutical interventions.
Description: Promotor: Th. J. van Berkel, Co-promotor: M. van Eck
With summaries in Dutch and Chinese
Faculty: Leiden University Medical Center (LUMC)
Citation: Dan, Y., 2008, Doctoral thesis, Leiden University
ISBN: 9789074538688
Sponsor: The thesis was financially supported by the Chinese Scholarship Council. Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
Handle: http://hdl.handle.net/1887/13220
 

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