Regulation of endosomal and phagosomal transport

Leiden Repository

Regulation of endosomal and phagosomal transport

Type: Doctoral Thesis
Title: Regulation of endosomal and phagosomal transport
Author: Kuijl, Coenraad Paul
Publisher: Division of Tumor Biology of the Netherlands Cancer Institute, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2008-10-15
Keywords: Endocytosis
Phagocytosis
Rab7
RILP
Salmonella
Cholesterol
Rab14
Abstract: Endocytosis can be conceptually broken down into two stages: The formation of the nascent vesicle containing the ingested proteins and lipids, and its subsequent maturation into a degradative compartment. During this maturation process proteins can be recycled back to the plasma membrane to prevent degradation. The vesicular membrane and the luminal contents undergo considerable remodeling to transform this compartment into a degradative one. This stops signal transduction by degrading the receptors within the vesicle and also generates antigens for presentation on MHC class II molecules in order to elicit an adaptive immune response. The engulfment of large particles and microorganisms (e.g. pathogens) is referred to as phagocytosis. The vesicle created by phagocytosis is called the phagosome. Phagosome maturation is considered to involve a complex sequence of fusion and fission events with the sub compartments of the endocytic pathway. In many ways, phagosome maturation recapitulates the progression of cargo along the endocytic pathway. In this thesis we have described molecular mechanisms that regulate the endocytic route and how pathogens explore this endocytic route to ensure survival.
Description: Promotor:J.J. Neefjes
With Summary in Dutch
Faculty: LUMC
Citation: Kuijl, C.P., 2008, Doctoral Thesis, Leiden University
Sponsor: Nederlands Kanker Instituut Nederlandse Vereniging voor Microscopie Koningin Wilhelmina Fonds
Handle: http://hdl.handle.net/1887/13146
 

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application/pdf Introduction 1.614Mb View/Open
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application/pdf Summary in English 103.7Kb View/Open
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