Computers and drug discovery : construction and data mining of chemical and biological databases

Leiden Repository

Computers and drug discovery : construction and data mining of chemical and biological databases

Type: Doctoral Thesis
Title: Computers and drug discovery : construction and data mining of chemical and biological databases
Author: Kazius, Jeroen
Publisher: Division of Medicinal Chemistry, Leiden-Amsterdam Center for Drug Research (LACDR), Faculty of Science, Leiden University
Issue Date: 2008-06-11
Keywords: Cheminformatics
Chemoinformatics
Bioinformatics
Databases
Data mining
Drug discovery
SNPs
Polymorphisms
Substructures
Abstract: In general, biological and chemical causes for harmful effects were studied through bioinformatics and cheminformatics efforts. A database of human genetic variants in G protein-coupled receptors was constructed, and differences between neutral and harmful variants were studied. A database of compounds with their mutagenicity data was constructed, and substructures were extracted that distinguish between Ames positive and Ames negative compounds. 6. Keywords (At most 10, in English), preferably from the thesaurus in use within your discipline. Do not use very general terms. cheminformatics, chemoinformatics, bioinformatics, databases, data mining, drug discovery, SNPs, polymorphisms, substructures.
Description: Promotores: A.P. IJzerman, J.N. Kok With Summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Kazius, J., 2008, Doctoral thesis, Leiden University
ISBN: 9789090229645
Handle: http://hdl.handle.net/1887/12954
 

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application/pdf Title pages_Contents 87.77Kb View/Open
application/pdf Chapter 1 209.8Kb View/Open
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application/pdf Chapter 3 1.019Mb Under embargo Full text at publisher site
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application/pdf Summary in English 27.91Kb View/Open
application/pdf Summary in Dutch 30.61Kb View/Open
application/pdf Curriculum Vitae_Publications_Acknowledgements 27.75Kb View/Open
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