Towards adoptive cellular therapy of chronic autoimmune arthritis

Leiden Repository

Towards adoptive cellular therapy of chronic autoimmune arthritis

Type: Doctoral Thesis
Title: Towards adoptive cellular therapy of chronic autoimmune arthritis
Author: Flierman, Roelof
Publisher: Department of Rheumatology, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2008-01-23
Keywords: Alloreactivity
Bone Marrow Transplantation
Collagen-Induced Arthritis
NK Cells
Regulatory T Cells
Rheumatoid Arthritis
Abstract: Rheumatoid arthritis (RA) is a relatively common disease that is characterized by chronic inflammation of joints. The research as described in this thesis focused on the question of whether adoptive cellular therapy is effective in a mouse model of RA. The most generally known type of adoptive cellular therapy is, probably, bone marrow transplantation (BMT), i.e. BM cells from a healthy donor are transplanted to the patient. Especially, hematological disorders like leukemia are treated with BMT; however, the research presented in this thesis strongly suggests that BMT may also effectively treat diseases, such as RA, in the (near) future. The efficacy of other types of adoptive cellular therapies was also investigated, including the transfer of regulatory T cells. Most strikingly, the disappearance of autoaggressive immune cells was associated with the efficacy of the treatment. These results suggest that these immune cells that, directly or indirectly, cause damage to the patient’s joints were eliminated and/or were kept quiescent. These studies are of importance for the future improvement of the treatment of rheumatic diseases like RA.
Description: Promotors: T.W.J. Huizinga, J.M. van Laar, Co-promotor: R.E.M. Toes
With summary in Dutch
Faculty: LUMC
Citation: Flierman, R., 2008, Doctoral thesis, Leiden University
Sponsor: Dutch Arthritis Foundation Novartis Pharma B.V. BD Biosciences Bos Pianoservice, Bodegraven

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