Early life experience : neuroendocrine adaptations to maternal absence

Leiden Repository

Early life experience : neuroendocrine adaptations to maternal absence

Type: Doctoral Thesis
Title: Early life experience : neuroendocrine adaptations to maternal absence
Author: Enthoven, Leo
Publisher: Department of Medical Pharmacology, part of the Leiden/Amsterdam Center for Drug Research, Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2007-10-04
Keywords: ACTH
HPA axis
Maternal care
Maternal deprivation
Repeated separations
Abstract: An adverse early life event is considered a risk factor for stress-related psychiatric disorders in genetically predisposed individuals, probably because of its lasting effect on susceptibility to stress. The objective of this thesis research was to examine in the mouse CD1 strain the immediate and permanent effects of an adverse early experience on the neuroendocrine stress system. For this purpose the hypothalamic-pituitary-adrenal (HPA) axis was examined of mouse pups that were refrained from maternal care, a laboratory model for neglect mimicking aspects of abuse. The data show that the infants’ stress response system readily adapts to daily repeated 8 hours of maternal separation, but that it continues to respond to a novelty stressor. The rapid adaptation to repeated maternal absence seems rather due to the ability to predict return of the mother than to adjust metabolism to episodic food deprivation. If maternal separation was extended to a single episode of 24 hours the immediate outcome was more profound but transient, although subtle effects on stress reactions and cognitive performance did persist. The findings demonstrate the amazing plasticity of the newborn brain and provide a basis to study the mechanistic underpinning of vulnerability or resilience to psychopathology.
Description: Promotoren: E.R. de Kloet, M.S. Oitzl
With summary in Dutch
Faculty: LUMC
Citation: Enthoven, L., 2007, Doctoral thesis, Leiden University
ISBN: 9789090221977
Sponsor: Leiden/Amsterdam Center for Drug Research; Statistics Netherlands; J.E. Jurriaanse Stichting
Handle: http://hdl.handle.net/1887/12379

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application/pdf Cover 213.9Kb View/Open
application/pdf Title page_Table of contents_Preface 85.32Kb View/Open
application/pdf Chapter 1 Introduction 615.7Kb View/Open
application/pdf Chapter 2 507.3Kb View/Open
application/pdf Chapter 3 395.2Kb View/Open
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application/pdf Chapter 5 237.3Kb View/Open
application/pdf Chapter 6 391.7Kb View/Open
application/pdf Chapter 7 General discussion 343.1Kb View/Open
application/pdf Summary_Summary in Dutch 154.7Kb View/Open
application/pdf List of abbrevi ... lum vitae_Acknowledgements 143.3Kb View/Open
application/pdf Appendix I 181.6Kb View/Open
application/pdf Propositions 29.15Kb View/Open

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