Viral elements inducing tumor-related apoptosis

Leiden Repository

Viral elements inducing tumor-related apoptosis

Type: Doctoral Thesis
Title: Viral elements inducing tumor-related apoptosis
Author: Kooistra, Klaas
Publisher: Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
Issue Date: 2007-10-11
Keywords: Apoptosis
Avian virus
Molecular pathways
P53-independent
Protein
Tumor-related
Tumor-specific way.
Viral elements
Abstract: In 1997, Danen-Van Oorschot et al. described for the first time that apoptin, a protein encoded by an avian virus, induces p53-independent apoptosis in a tumor-specific way. Various pre-clinical studies in animal tumor models have demonstrated apoptin as a safe and efficient anti-tumor agent. In tumor cells, apoptin is imported into the nucleus prior to the induction of apoptosis and regulated by a kinase activity specifically present in cancer cells. In this thesis, several studies have been carried out to reveal the novel aspects of the molecular pathways underlying the transformation-related apoptosis induction by the viral protein apoptin.
Description: Promotor: M.H.M. Noteborn, Co-promotor: Y.H. Zhang
With summary in Dutch
Faculty: Faculteit der Wiskunde en Natuurwetenschappen
Citation: Kooistra, K., 2007, Doctoral thesis, Leiden University
ISBN: 9789090221779
Handle: http://hdl.handle.net/1887/12375
 

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