Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases

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Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases

Type: Doctoral Thesis
Title: Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases
Author: Kytidou, K.
Issue Date: 2020-06-25
Keywords: Glycosidases
Plants
Lysosomal storage diseases
Fabry disease
Alpha galactosidases
Nicotiana benthamiana
Abstract: The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases. Activity-based probes are a versatile research tool in many of the investigations on glycosidases and are examined regarding diagnostic application. A specific element of the thesis investigations is the focus on plants, either as source of endogenous glycosidases as well as production platform for therapeutic human enzymes.
Promotor: Supervisor: Aerts J.M.F.G. Co-Supervisor: Boot R.G.
Faculty: Faculty of Science
University: Leiden University
Handle: http://hdl.handle.net/1887/123040
 

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application/pdf Acknowledgement ... vitae_List of publications 352.9Kb View/Open
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