Quantum virology : improved management of viral infections through quantitative measurements

Leiden Repository

Quantum virology : improved management of viral infections through quantitative measurements

Type: Doctoral Thesis
Title: Quantum virology : improved management of viral infections through quantitative measurements
Author: Kalpoe, Jaijant Satishkumar
Publisher: Department of Medical Microbiology, Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2007-06-28
Keywords: Adenovirus
Area under the viremia curve
Cytomegalovirus
Epstein-Barr virus
Nasopharyngeal disease
Post transplant lymphoproliferative
Real-time PCR
(Val)ganciclovir
Varicella-zostervirus
Virus quantitation
Abstract: Real-time monitoring of PCR has strongly supported the increased diagnostic use of nucleic acid detection assays in clinical virology. Particularly the improvements in the ability to quantify target nucleic acid sequences offer new opportunities in the management of viral infections. Real-time PCR is rapidly replacing traditional PCR, and new diagnostic uses will likely emerge. This thesis explores the wide range of potential applications of real-time quantitative PCR technology in clinical virology. This exploration is directed to the design of methods, the application to relevant patient categories, the comparison with established methods where available, and the definition of the clinical relevance of the approach. The focus comprises viral targets where an elaborate balance between viral replication and the host immune system has been established, which brings about viral maintenance without affecting the host, until this balance is disturbed.
Description: Promotor: A.C.M. Kroes
With summary in Dutch
Faculty: LUMC
Citation: Kalpoe, J.S., 2007, Doctoral thesis, Leiden University
ISBN: 9789064641466
Handle: http://hdl.handle.net/1887/12100
 

Files in this item

Description Size View
text/html Links to published articles 21.6Kb View/Open
application/pdf Cover 2.405Mb View/Open
application/pdf Full text 3.358Mb View/Open
application/pdf Propositions 482.3Kb View/Open

This item appears in the following Collection(s)