Hyperlipidemia, inflammation and atherosclerosis : roles of apolipoprotein C1 and cholesteryl ester transfer protein

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Hyperlipidemia, inflammation and atherosclerosis : roles of apolipoprotein C1 and cholesteryl ester transfer protein

Type: Doctoral thesis
Title: Hyperlipidemia, inflammation and atherosclerosis : roles of apolipoprotein C1 and cholesteryl ester transfer protein
Author: Westerterp, Marit
Publisher: Department of General Internal Medicine, Endocrinology, and Metabolic Diseases, Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2007-06-12
Keywords: Apolipoprotein CI
Atherosclerosis
Cardiovascular disease
Cholesteryl ester transfer protein
Hyperlipidemia
Inflammation
Lipoprotein metabolism
Transgenic mouse models
Abstract: The main cause of cardiovascular disease (CVD) is atherosclerosis. Several genes that affect atherosclerosis development have been identified by the use of genetically modified mice (i.e. transgenic and knock-out mouse models). Many of these genes exert their role in atherosclerosis development as a result of effects on lipoprotein metabolism and inflammation. Transgenic mouse models have also been proven to be suitable for evaluating the mechanisms underlying the anti-atherosclerotic action of experimental drugs aimed to reduce atherogenic lipoprotein levels. However, thus far no suitable animal model was present to evaluate the mechanism of action of anti-atherosclerotic effect of HDL-raising therapeutic strategies. In this thesis, we further explored the role of apolipoprotein CI (apoCI) and cholesteryl ester transfer protein (CETP) in lipoprotein metabolism, inflammation, and atherosclerosis. Furthermore, we developed a mouse model that will be suitable for testing potential high-density-lipoprotein (HDL) raising therapies as a novel strategy to treat CVD.
Description: Promotor: L.M. Havekes, Co-promotor: P.C.N. Rensen
With summary in Dutch
Faculty: LUMC
Citation: Westerterp, M., 2007, Doctoral thesis, Leiden University
ISBN: 9789090219264
Handle: http://hdl.handle.net/1887/12043
 

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