Automated segmentation of atherosclerotic arteries in MR Images

Leiden Repository

Automated segmentation of atherosclerotic arteries in MR Images

Type: Doctoral Thesis
Title: Automated segmentation of atherosclerotic arteries in MR Images
Author: Adame Valero, Isabel Maria
Publisher: Laboratory for Clinical en Experimental Image processing, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
ASCI graduate school
Issue Date: 2007-04-04
Keywords: Atherosclerosis
Carotid Arteries
Image processing
Magnetic Resonance
Model-based segmentation
Plaque Burden
Vessel Wall Imaging
Abstract: Accurate visualization and quantification of atherosclerosis in a non-invasive manner by means of MR is, nowadays, of high importance, not only regarding morphology but also composition of the atherosclerotic plaques. MR has proven to be capable of detecting early, subclinical vulnerable plaque. However, when the analysis of atherosclerosis is based on visual interpretation of the images or manually delineated structures, the outcome is often not reliable. The main objective of this thesis was to investigate novel image processing techniques to automatically quantify markers of the severity of atherosclerosis in a reproducible manner, by automatically outlining the boundaries of the blood vessel wall, lumen and plaque burden. Different algorithms have been developed and applied to different vascular beds (aorta and carotid arteries) proving to be versatile and powerful tools, that provide quantitative reproducible parameters. These new techniques have been validated in limited populations, proving to be accurate and reproducible. They are, therefore, suitable to be further adapted and to be employed in the clinical vascular research. This assists the physician in making a diagnosis and identifying high-risk patients, who may benefit from treatment.
Description: Promotor: J.H.C. Reiber, Co-promotores: B.P.F. Lelieveldt, R.J. van der Geest
With summary in Dutch
Faculty: LUMC
Citation: Adame Valero, I.M., 2007, Doctoral thesis, Leiden University
Series/Report no.: ASCI dissertation series
ISBN: 9090211144
Sponsor: Financial support for chapters 3-5 was provided by the Marie Curie Industry Host Fellowship (grant HPMI-CT-2002-00175). Chapter 5 was also supported by contracts N01-HC-95159, N01 HC 95162, and N01 HC 95168 from the National Heart, Lung, and Blood Institute. The research described in chapters 6 and 7 was financially supported by the Dutch Science Foundation (NWO), under an innovational research incentive grant nr. 016.026.017.

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application/pdf Chapter 7 1.431Mb View/Open
application/pdf Chapter 8 Summary and conclusions 122.0Kb View/Open
application/pdf Chapter 9 Summary and conclusions in Dutch 123.4Kb View/Open
application/pdf Publications 156.7Kb View/Open
application/pdf Acknowledgements 98.75Kb View/Open
application/pdf Curriculum Vitae 98.28Kb View/Open
application/pdf Glossary 141.8Kb View/Open
application/pdf Index of Figures 107.6Kb View/Open
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