Induction and analysis of antigen-specific T cell responses in melanoma patients and animal models

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Induction and analysis of antigen-specific T cell responses in melanoma patients and animal models

Type: Doctoral Thesis
Title: Induction and analysis of antigen-specific T cell responses in melanoma patients and animal models
Author: Bins, Adriaan Dirk
Publisher: Leiden University Press
Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2007-03-15
Keywords: Antigen
Cross presentation
DNA vaccination
In vivo imaging
Melanoma
Stability
T cells
Tattoo
Tetramers
Vaccination
Abstract: This thesis introduces a novel T cell vaccination method that uses a tattoo machine to inject DNA in the skin of the vaccinee. In comparison to other experimental vaccination methods DNA tattooing is very strong: besides small laboratory animals also large animals mount strong T cell responses upon tattoo DNA vaccination.
Description: Promotor: T.N.M. Schumacher, Co-promotor: J.B.A.G. Haanen
With summary in Dutch
Faculty: LUMC
Citation: Bins, A.D., 2007, Doctoral thesis, Leiden University
Series/Report no.: LUP dissertations
ISBN: 9789087280116
Sponsor: Netherlands Cancer Institute / Antoni van Leeuwenhoek Hospital. Dutch cancer foundation
Handle: http://hdl.handle.net/1887/11457
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application/pdf Introduction 484.0Kb View/Open
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application/pdf Chapter 6 10.52Mb View/Open
application/pdf Chapter 7 1.917Mb View/Open
application/pdf Discussion 448.5Kb View/Open
application/pdf Summary in Dutch 405.6Kb View/Open
application/pdf Acknowledgements_Curriculum Vitae 466.7Kb View/Open
application/pdf Invitation_Propositions 1.050Mb View/Open

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