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Advancing forensic RNA profiling
In forensic science, next to the question of who contributed to the trace (DNA analysis), knowledge regarding the cellular origin of the evidentiary trace, thus what cell type contributed to the trace, is often key to facilitate inference of activities. To this aid, RNA-based approaches have shown their up come in forensic investigations since 1999. RNA profiling techniques rely on the fact that different cell types, such as blood, express a characteristic pattern of genes, such as haemoglobin beta (HBB) expressed in the red blood cells. This thesis describes studies that assisted the expanding and advancement of forensic RNA profiling assays used for the inference of body fluids and organ tissues.
- All authors
- Berge, M.W. van den
- Supervisor
- Knijff, P. de
- Co-supervisor
- Sijen, L.M.T.
- Committee
- Tijsterman, M.; Kayser, M.; Harbison, S.A.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Medicine / Leiden University Medical Center (LUMC) , Leiden University
- Date
- 2018-06-28
- ISBN
- 9789082749038
Funding
- Sponsorship
- The research described in this thesis has been performed within the Research group of the Biological Traces division at the Netherlands Forensic Institute. This work was financially supported by the European Union Seventh Framework Programme (FP7/2007- 2013) under grant agreement n° 285487 (EUROFORGEN-NoE). Publication of this thesis was financially supported by the Netherlands Forensic Institute.